There are several factors that come into play with the 10-bolt. One is the power level, another is traction, and another is driving style. If you have a stick shift, put on sticky tires, and head to the drag strip, the life expectancy of the unit will be fairly short even with 300 horsepower. If you have stock tires (not drag radials), a Powerglide, and you drive sanely, it will last much longer, even with 500 horsepower. Wheel hop under acceleration is a prime consideration. That will take out the axles sooner rather than later. Putting in a posi-traction will enhance traction but better traction leads to wheel hop unless you use a slapper bar or other device designed to control wheel hop. Those parts are not bullet-proof and if you challenge them, eventually you're going to come home on the hook. You will control your own destiny through your driving style.