I believe the difference is in the accelerator pump discharge circuit as the manual shift cars produce more HC than the automatics due to the constant action of the accelerator pump while shifting through the gears. Once you are in high gear, manual or automatic, they are, for the most part, the same. I can't think of any reason for the throttle plates or jetting to be different. If I had the 02 carb I would not hesitate to use it on my manual car. They, Qaudrajets, were hardly what I would call an accurate carburetor. Crude would be closer to the truth especially compared to Holleys or even more so fuel injection. That's why you don't see them any longer.
High HCs are also why the manual shift cars got the A.I.R. pump. Manual cars produce excessive HC everytime the accelerator pump is operated so the engineers installed a pump that supplied fresh air in to the exhaust manifold to act as sort of an afterburner to burn the HC (unburned gasses) while still present in the exhaust stream. Supplying fresh air in to the exhaust stream was just the ingredient needed to start a fire in the exhaust combining unburned fuel, fresh air and heat. Very crude but very effective. By the time the exhaust reached the tail pipe the HC was mostly burned away.